For a relativistic bipartite system, you usually do not start with a simple Hamiltonian likeH=HAIB+IAHB+HintH = H_A \otimes I_B + I_A \otimes H_B + H_{\text{int}}H=HA​⊗IB​+IA​⊗HB​+Hint​

unless you are in a special approximation. The relativistic treatment changes the framework.

The main issue is this:Relativity treats space and time together, but ordinary Hamiltonians single out time.\boxed{ \text{Relativity treats space and time together, but ordinary Hamiltonians single out time.} }Relativity treats space and time together, but ordinary Hamiltonians single out time.​

So the more natural object is the action or the field theory Lagrangian, not a nonrelativistic two-particle Hamiltonian.

For two relativistic particles/fields, one writes something likeS=d4xLA+d4xLB+d4xLintS = \int d^4x \, \mathcal L_A + \int d^4x \, \mathcal L_B + \int d^4x \, \mathcal L_{\text{int}}S=∫d4xLA​+∫d4xLB​+∫d4xLint​

or, schematically,L=LA+LB+Lint\mathcal L = \mathcal L_A + \mathcal L_B + \mathcal L_{\text{int}}L=LA​+LB​+Lint​

For two scalar fields,LA=12μϕAμϕA12mA2ϕA2\mathcal L_A = \frac12 \partial_\mu \phi_A \partial^\mu \phi_A – \frac12 m_A^2\phi_A^2LA​=21​∂μ​ϕA​∂μϕA​−21​mA2​ϕA2​ LB=12μϕBμϕB12mB2ϕB2\mathcal L_B = \frac12 \partial_\mu \phi_B \partial^\mu \phi_B – \frac12 m_B^2\phi_B^2LB​=21​∂μ​ϕB​∂μϕB​−21​mB2​ϕB2​

and an interaction might beLint=gϕA2ϕB2\mathcal L_{\text{int}} = -g \phi_A^2 \phi_B^2Lint​=−gϕA2​ϕB2​

Then the relativistic dynamics comes fromδS=0\delta S = 0δS=0

rather than from a simple two-body Schrödinger Hamiltonian.

For quantum theory, the state lives in a tensor product of field Hilbert spaces:H=HAHB\mathcal H = \mathcal H_A \otimes \mathcal H_BH=HA​⊗HB​

but the particles are excitations of fields, not little objects with fixed wavefunctions.

A bipartite relativistic state might look likeΨ=p,qC(p,q)aA(p)aB(q)0|\Psi\rangle = \sum_{p,q} C(p,q) \,a_A^\dagger(p) a_B^\dagger(q) |0\rangle∣Ψ⟩=p,q∑​C(p,q)aA†​(p)aB†​(q)∣0⟩

where aA(p)a_A^\dagger(p)aA†​(p) creates particle AAA with four-momentum ppp, and aB(q)a_B^\dagger(q)aB†​(q) creates particle BBB with four-momentum qqq.

The relativistic energy isEp=p2+m2E_{\mathbf p} = \sqrt{\mathbf p^2 + m^2}Ep​=p2+m2​

so the free Hamiltonian is roughlyH0=d3p(2π)3EpapapH_0 = \int \frac{d^3p}{(2\pi)^3} E_{\mathbf p} \,a^\dagger_{\mathbf p}a_{\mathbf p}H0​=∫(2π)3d3p​Ep​ap†​ap​

For two species,H0=d3p(2π)3EpAaA(p)aA(p)+d3q(2π)3EqBaB(q)aB(q)H_0 = \int \frac{d^3p}{(2\pi)^3} E^A_{\mathbf p} a_A^\dagger(\mathbf p)a_A(\mathbf p) + \int \frac{d^3q}{(2\pi)^3} E^B_{\mathbf q} a_B^\dagger(\mathbf q)a_B(\mathbf q)H0​=∫(2π)3d3p​EpA​aA†​(p)aA​(p)+∫(2π)3d3q​EqB​aB†​(q)aB​(q)

Then add an interaction Hamiltonian:H=HA+HB+HintH = H_A + H_B + H_{\text{int}}H=HA​+HB​+Hint​

But now HintH_{\text{int}}Hint​ comes from a Lorentz-invariant field interaction.

So the relativistic version of the bipartite Hamiltonian idea is:HAI+IHB+Hint\boxed{ H_A \otimes I + I \otimes H_B + H_{\text{int}} }HA​⊗I+I⊗HB​+Hint​​

but interpreted in QFT, where HAH_AHA​, HBH_BHB​, and HintH_{\text{int}}Hint​ act on field Fock spaces.

The clean hierarchy is:Nonrelativistic QM: two-particle Hamiltonian\boxed{ \text{Nonrelativistic QM: two-particle Hamiltonian} }Nonrelativistic QM: two-particle Hamiltonian​ Relativistic QM: constrained and delicate\boxed{ \text{Relativistic QM: constrained and delicate} }Relativistic QM: constrained and delicate​ Relativistic QFT: fields, Fock space, Lorentz-invariant action\boxed{ \text{Relativistic QFT: fields, Fock space, Lorentz-invariant action} }Relativistic QFT: fields, Fock space, Lorentz-invariant action​

So the safest answer is:Treat the bipartite system as two interacting quantum fields.\boxed{ \text{Treat the bipartite system as two interacting quantum fields.} }Treat the bipartite system as two interacting quantum fields.​

Not as two particles with an ordinary potential V(xAxB)V(\mathbf x_A-\mathbf x_B)V(xA​−xB​), because instantaneous potentials generally conflict with relativity.